Scaffold Hopping in Medicinal Chemistry
By:Nathan Brown
Published on 2013-11-06 by John Wiley & Sons
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.
This Book was ranked at 20 by Google Books for keyword chemistry core.
Book ID of Scaffold Hopping in Medicinal Chemistry's Books is ZY8KAgAAQBAJ, Book which was written byNathan Brownhave ETAG "n4BubF6YsNo"
Book which was published by John Wiley & Sons since 2013-11-06 have ISBNs, ISBN 13 Code is 9783527665167 and ISBN 10 Code is 3527665161
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